Adrenalin / Adrenaline Products & Services for the 21st Century

CLOtherapy... STRESS PRE-VENTING POLO-SHIRT COOLS NERVES

Stress is becoming an increasingly important health issue in the international workplace, reported upon repeatedly by the Media, especially in the warmer summer months as more office Staff and exam Students reach boiling point and in some instances burn-out. So how then can 'CLOtherapy' help our nerves to simply remain cooler, calmer and more collected ...each time the stress gets too much and puts Us in the hot seat?

http://www.adrenalin.tm *PRESS RELEASE*

Adrenaline-REsearch, at the Tweed Horizons Centre for Sustainable Technology in Melrose, Scotland, have been studying the effects of temperature control and clothes in relation to Humans' ability to control their own temper. Adrenaline found that our central nervous system - more than 3lbs of vital nerve wiring which makes up our brain & spinal cord, is very sensitive to changes in temperature.

International 'thermo-regulatory' research suggests that the spinal cord responds like a thermostat to protect our delicate nerve cells from excess heat, either by trying to adapt by reducing nervous activity and so slowing down the body, making Us sleepy, when the heat is on - or by increasing sweating or shedding hair - a cooling mechanism which operates to help sweat evaporate and heat escape, more freely, from the skin's surface.

According to Adrenaline - "Temperature sensitive pictures of the human body called 'thermograms', show that the brain & spinal cord warms up rapidly as stress increases, and sometimes You can even feel this, for instance when We feel those shivers up and down our spine - that's to help 'warm-up' the efficiency of the flow of information along our 'bio-electrical' spinal nerve wiring, and this then helps Us to cope with increased stressful demands upon the body - with our nerves working more effectively."

PHILOSOPHY - COOL UNDER THE COLLAR

20th Century traditional office dress including 'collar & tie', always covers the length of our temperature sensitive 'spinal thermometer' with insulating fabric, so it appears that a cool new scientific fashion philosophy may well be beneficial to the nervous system of the temperature conscious office Worker of the 21st Century.

Scientists at Adrenaline-REsearch have designed & patented a special CLOtherapy Polo-shirt, smart enough to be sported at the office or at leisure, all year round - and whilst the shirt is fashioned much like 'conventional' polo-shirts, each shirt uniquely includes a cool 'ADRENALIN' fabric zone along the length of the spine.

With gentle warm-up exercises, such as daily lunchtime walks, chilling-out wearing the CLOtherapy Polo-shirt, the cool spinal air-conditioning encourages and trains a healthy thermo-regulatory response, a biochemical change which research suggests can gradually improve blood circulation, brown fat function and muscle tone.

Similar to cold water hydrotherapy and the established thermo-regulatory benefits of invigorating the nervous system with daily cold baths - cool polo-shirt CLOtherapy also allows the Wearer to conveniently massage and gently refresh their spinal nerves several times a day, for life, without any need to get wet.

This new 'stress-adaptive' treatment is both sustainable and comfortable because a warmer outer layer of clothes can easily be added, and so cover the polo-shirt's Adrenalin fabric zone when too cool and then be removed when too warm - it is these temperature changes which help to fortify the Wearer's spinal CLOtherapy.

CLOtherapy Polo-shirts, available in navy, made-to-order at £59.95, are also claimed to have an increased feel good comfort factor, which can even help improve the vitality of your sports performance - again by encouraging a cool-head. A free CLOtherapy fact sheet is available from Adrenaline-REsearch on Tel/Fax:(07000) 256-843.

EDITORS PLEASE KEEP YOUR HAIR ON & CONTACT:-
Trevor K. Gunn, (Medical Biochemist/Registered Homeopath) - Tel/Fax:(07000) 237-362,
Nicholas Dynes Gracey, (Medical Biochemist/Clothes Inventor) - mailto:[email protected]
Text, picture(s), references & thermogram(s) may be downloaded directly from 'http://www.clotherapy.com'

Editors interested in a free prototype CLOtherapy Polo-shirt for photography/testing should fax a request on their Company headed notepaper; Please always include a fax number and quote ref: T114PR01.

CLOtherapy... Polo-shirts, likely the healthiest polo-shirts in the world, are designed to enhance the human thermoregulatory and immune system by encouraging youthful healthy body temperatures and preventing overheating and excessive perspiration. By redressing your spinal cord with adrenalin.tm fabric technology incorporating adrenalin.tm net along the whole backbone, and worn in conjunction with adrenalin.tm training tips, the promise is that your brain & spinal cord is repeatedly revitalized with the help of efficient heat exchange and cool air massaging via the patented adrenalin.tm comfort coolzone, ingeniously designed to help warm-up the blood & nerve flow along the length of your temperature sensitive spine...

The general rule is that the younger and healthier a Human Being, the greater their ability to generate internal warmth. Internal warmth generation, especially 'up and down the spine', is a normal part of the 'immune response' and key to the way the body raises its activity to deal with stress. 'Thermograms', temperature sensitive pictures, taken without clothes in a 22ºC room show that a healthy Child generates internal spinal warmth along the full length of his/her spine. Adrenaline-REsearch have intensively researched this immune system phenomenon, the result of which is CLOtherapy... 'The science of encouraging sustainable environmental & temperATure control' ...Let it Flow!

A youthful spinal cord contains a high concentration of nerves - which can sense and respond to cool temperatures by increasing vitality & warmth, thereby helping to maintain body temperature around 37ºC. Medical research and thermogram photographs suggest that average body temperatures decline from about age 11 gradually through to the elderly average which is often well below 37ºC. CLOtherapy Polo-shirts all include the internationally patented adrenalin.tm comfort zone along the spine, both to help facilitate youthful vitality and to help encourage all Wearers to actively focus upon regular spine-strengthening 'warm-up' training, thereby gradually helping to improve brown fat function, blood & lymphatic circulation and most importantly - nerve flow along their vital spinal cord 'nervous system network';

*FREE adrenalin.tm TRAINING TIPS *COOL IN SUMMER *WARM IN WINTER *AIR MASSAGES SPINE *ENCOURAGES VITALITY*

*FEELS GOOD*CHIC EMBROIDERY *MONEY BACK GUARANTEE *21st CENTURY SMART TECHNOLOGY*POLO-SHIRT*

'Weight Control' is profoundly linked to the spinal nerves naturally learning to respond to excessive warmth - (a) because - by reducing warmth generating nerve activity, their delicate fatty-nerve tissue (myelin) and DNA is protected from 'overheating', driving the body, protectively, in the direction of sleepy siesta mode (aestivation) - and (b) because excessive warmth can also lead to muscle breakdown (catabolism) and hair shedding (moulting) in an adaptive protective attempt to shed excessive heat-trapping insulation. Adrenaline-REsearch are seeking Distributors, and offer a global adrenalin.tm manufacturing made-to-order-service for CLOtherapy Polo-shirts, made to your size in many traditional colours & delivered, worldwide, right to your door (currently within 42 days)... The new improved CLOtherapy Polo-shirt, launched in Summer'98 at £59.95, now combines cool, breathable adrenalin.tm fabric technology for 'air-trapping' body warmth with a spinal zone of adrenalin.tm net, thereby creating a unique 'air-massage' along the spinal cord nerves (!), efficiently helping encourage all Wearers to realize a sustainable 'CLOtherapy Lifestyle' - stimulating and facilitating those vital nerves to generate warmth, more youthfully, at all temperatures - encouraging the Underweight to process more calories/cholesterol into muscle, and Overweight to convert more calories/cholesterol to internal warmth generation ...Please experience this latest health breakthrough... Enjoy your CLOtherapy Polo-shirt for 30 days of improving comfort & vitality, or simply return for a prompt refund. CLOtherapy Polo-shirts are currently available, for fast delivery, in Navy XL at £59.95 + £2.95 p&p, Mail Order (within 28 days), from Adrenaline-REsearch, Tweed Horizons, Centre for Sustainable Technology, Melrose, Scotland, TD6 0SG, UK.

Fax: +44 (0) 7000 - adrenalin.tm (237-362) .......... E-mail: [email protected] .......... +44 (0) 7000 - CLOtherapy... (256-843)




	*CLOTHERAPY/CLOTHING* Q. What is CLOtherapy clothing? A. CLOtherapy clothing incorporates the "CLOtherapy PHILOSOPHY" which facilitates optimum temperature regulation.
	*CLOTHERAPY/"CLOTHING PHILOSOPHY"* Q. What is the "CLOtherapy PHILOSOPHY"? A. The patented "CLOtherapy PHILOSOPHY" mirrors the way the body clothes itself naturally - quite simply, less fabric where there is less bulky white fat (armpits, backbone, breastbone and groin) and more fabric in the more fatty areas.
	*RESEARCH/MATERIAL* Q. Does Adrenaline-REsearch conduct laboratory research - what is the nature of the research? A. Adrenaline-REsearch studies worldwide medical/scientific literature from pre-Hippocrates right through to the latest scientific research.
	*RESEARCH/TEMPERATURE AND HEALTH* Q. What does Adrenaline- REsearch do? A. Adrenaline-REsearch is a research group studying how temperature affects our health and performance.
	*RESEARCH/ "THEORY OF HEALTH"* Q. What is the Adrenaline- REsearch "Theory of Health"? A. Adrenaline-REsearch believes that optimum health depends on optimum temperature regulation.
	*RESEARCH/ "THEORY OF HEALTH"/CLOTHERAPY* Q. What is CLOtherapy? A. CLOtherapy is based on the Adrenaline-REsearch "Theory of Health" and is all about facilitating the body's internal temperature regulation.
	*RESEARCH/THEORY/CLOTHERAPY/QUESTIONS* Q. Where should you send your questions about the Adrenaline- REsearch "Theory of Health" and CLOtherapy? A. Adrenaline-REsearch welcomes letters about the Adrenalin "Theory of Health" and CLOtherapy as these greatly assist the research... Please e-mail:- [email protected]
	*BROWN FAT/BULKY WHITE FAT REDUCTION* Q. How can CLOtherapy clothing help weight loss? A. Research suggests that cold can encourage brown fat to convert bulky white fat into heat, so by allowing for cold/cool stimulation of brown fat CLOtherapy can help you lose weight.
	*BROWN FAT/BULKY WHITE FAT REDUCTION/CONTROL* Q. How can CLOtherapy clothing help prevent excessive weight loss? A. By facilitating heat loss, particularly when the body is under heated nervous stress/fighting an infection, CLOtherapy clothing can help prevent excessive "burning" of insulatory white fat.
	*TEMPERATURE SENSITIVE TISSUE/DISTRIBUTION* Q. Why is it that just certain areas in particular (armpits, backbone, breastbone and groin) have less bulky white fat and sweat more? A. More sweat suggests these areas need to be able to lose heat easily and sweat properly - the "CLOtherapy design concept" provides for improved heat loss, e.g. by efficient convection, and sweat function, e.g. by efficient evaporation, in the sweaty areas.
	*BROWN FAT/COLD/WEIGHT CONTROL* Q. How can CLOtherapy clothing help you "control" your weight? A. CLOtherapy clothing allows for cold/cool stimulation and research suggests that while cold can encourage reduction of bulky white fat if you are overweight, it can promote weight gain if you are underweight.
	*BROWN FAT/BULKY WHITE FAT REDUCTION/SAFETY* Q. Does CLOtherapy clothing provide a safe way of shedding excess bulky white fat? A. Lots of temperature-sensitive tissues including brown fat, nervous tissue, important blood vessels, and glands such as the thymus gland and testicles, can be found there - the "CLOtherapy design concept" provides for increased temperature-sensitivity in these areas.
	*BROWN FAT/COLD* Q. Why is it important for your key brown fat areas to keep cool? A. Cold stimulates brown fat heat generation which can play a vital role in our health and performance.
	*BROWN FAT/DISTRIBUTION* Q. What are the "key" brown fat areas? A. Adrenaline-REsearch believes the key temperature sensitive areas of brown fat to be those with a minimal covering of bulky white fat - the "CLOtherapy design concept" provides minimal insulation and facilitates heat loss in these areas.
	*BROWN FAT/EXERCISE* Q. How can CLOtherapy clothing improve your performance? A. By helping you lose excess heat and sweat effectively, CLOtherapy clothing can encourage brown fat to generate heat and help promote a warm blood supply for your muscles.
	*BROWN FAT/HUMANS* Q. What evidence is there for brown fat in humans? A. Research involving outdoor workers in Finland shows increased brown fat in exposed areas - as CLOtherapy clothing exposes more of your body to the outdoor climate, it is likely then that brown fat growth will increase.
	*BROWN FAT/IMMUNE* Q. How can CLOtherapy clothing boost your immune system? A. Just as muscles need to warm up, so does your immune system - by encouraging brown fat to generate heat CLOtherapy clothing can help your immune system function more efficiently.
	*BROWN FAT/STRESS* Q. How can CLOtherapy make stress a positive experience? A. By facilitating heat loss CLOtherapy clothing can help regulate brown fat activity to maintain the required level of internal heat to cope with the stress, without the heat-accociated strain.
	*CLOTHING/APPEARANCE* Q. What does CLOtherapy clothing look like? A. Using traditional clothing designs CLOtherapy clothing simply incorporates lightweight mesh panels in the sweaty areas of low bulky white fat (arm pits, backbone, breastbone, and groin).
	*CLOTHING/COMFORT* Q. How comfortable is CLOtherapy clothing? A. By keeping you cool where your body needs it and warm where you need it, CLOtherapy clothing means you can stay cool when the heat is on and warm when it"s cool.
	*CLOTHING/ENQUIRIES* Q. Where should you send your technical queries? A. Drop Adrenaline-REsearch a line at:- ADRENALIN, Tweed Horizons, Centre for Sustainable Technology, Melrose, Scotland, TD6 0SG, UK (F): +44 (0) 7000-78-1212 (T): +44 (0) 7000-78-2434 Email: [email protected]
	*CLOTHING/LICENCES* Q. Where should you send your licensing enquiries? A. Adrenaline-REsearch welcomes any enquiries about manufacturing/distributing CLOtherapy under licence at:- ADRENALIN, Tweed Horizons, Centre for Sustainable Technology, Melrose, Scotland, TD6 0SG, UK (F): +44 (0) 7000-78-1212 (T): +44 (0) 7000-78-2434 Email: [email protected]
	*CLOTHING/SCOPE* Q. What clothing could the patented "CLOtherapy design concept" be applied to? A. In time all clothing could be made this way.
	*COLD/WEIGHT GAIN* Q. How can CLOtherapy clothing help you gain weight? A. Research suggests that cold can encourage the synthesis of lean tissue and fat in thinner people, so by allowing for cool/cold stimulation CLOtherapy clothing can help you gain weight.
	*FAT/DISTRIBUTION* Q. Why is there less bulky white fat in certain areas (armpits, backbone, breastbone and groin)? A. Less bulky white fat suggests these areas need less insulation - the "CLOtherapy design concept" provides less insulation in these areas.
	*MUSCLE TONE/COLD* Q. Why is cold good for muscle tone? A. Cold has been shown to improve muscle tone and nervous functioning - CLOtherapy clothing provides for cold stimulation.
	*SPINE/THERMOMETER* Q. Why is the CLOtherapy backbone panel so important? A. Like a thermometer, your spine gathers information about the temperature outside your body - the CLOtherapy backbone panel allows for increased temperature-sensitivity along your spinal thermometer.
	*SPINE/THERMOMETER/COLD* Q. What are the likely benefits of keeping your spine cool? A. Cool/cold temperature signals from your spinal thermometer are likely to encourage internal heat generation, which is vital for our health and performance.
	*SWEAT/DISTRIBUTION* Q. Why are certain areas more sweaty than others (armpits, backbone, breastbone and groin)? A. More sweat suggests these areas need to be able to lose heat easily and sweat properly - the "CLOtherapy design concept" provides for improved heat loss, e.g. by efficient convection, and sweat function, e.g. by efficient evaporation, in the sweaty areas.

92.04. Castles, P. (Editor) (1992): The Editor writes. Bodybuilding Monthly, Apr, p10.
‘Adrenaline have just developed a revolutionary new sweat top, designed specifically for athletes, bodybuilders and weight trainers to wear in the gym...the designers and manufacturers have created a completely new concept in gym wear, and it is likely that before long we will all be wearing the patented CLOtherapy sweat top.’

95.08. Thomas, T. (1995): Knowledge. The European MagAZine, Jul 28 - Aug 03, p15.
‘...A British company may have succeeded...help invigorate your entire nervous system and even help you lose weight...’

93.05. Stock, M.J. (Professor of Physiology & Leading Brown Fat Researcher) (1993): Keeping warm. Nature, 363, p108.
‘A revolutionary new type of clothing (CLOtherapy)’

95.01. Raffael, M. (1995): Fighting Flab. The Sunday Telegraph, Jan 22, p32.
‘ “CLOtherapy” range of shirts... The designs stimulate brown-fat activity and train the body “To convert more of its bulky white fat into heat”.’

93.04. Collins, M. (Radio 4 Presenter) (1993): You and Yours. Radio 4, 19 Apr 12:20.
‘The CLOtherapy T-shirts and trousers appear at first glance like most leisure clothes but the key...lies in the strategically placed mesh panels that allow air to circulate under the arms, along the breastbone, down the spine and around the groin.’

93.05. Graimes, N. (Editor) (1993): Can You Believe It? Vegetarian Living, May, p4.
‘This is where CLOtherapy - invented by a graduate in Medical Biochemistry - comes into its own. The clothing incorporates sections of a specific fabric which let key areas of your brown fat (armpits, spine, chest, groin) feel the outside temperature, allow excess heat to be lost and thus help your brown fat function efficiently.’

93.02. Moonlight, Capt. (1993): Captain Moonlight’s Notebook. Independent on Sunday, 28 Feb, p18.
‘The technique is called CLOtherapy and involves uncovering those parts of your body where brown fat accumulates; in other words the most sweaty parts - breastbone, armpits, groin and spine. Brown fat...has more blood than ordinary white and yellow fat, and cool temperatures encourage it to convert the other fats into energy. Think of the body as a house...when the central heating is running if you open all the windows more heat goes out and you use up more fuel.’

93.02. Baker, A. (1993): Preamble. Observer on Sunday , 28 Feb, p11.
“You’ll notice a completely different feeling (CLOtherapy clothing)”...Preamble asked John Garrow, Professor of Human Nutrition at St. Bartholemew’s Hospital, what he thought... ‘Brown fat exists in very small animals like mice and babies, human babies.’

94.07. Bean, A. (1994): Fat burning miracles! Slimmer Magazine , Jul, p24-25.
‘Thermo-Regulatory Clothing...A range of clothing designed to keep most of the body warm, called CLOtherapy (by Adrenaline-REsearch)...Cool certain regions of the body encouraging your “brown” fat to burn extra calories off as heat...encouraging your body to make more brown fat...help shed surplus “white” fat.’

93.01. Anderson, A. (Alun Anderson, Editor) (1993): Feedback. New Scientist, 30 Jan, p88.
‘Adrenaline-REsearch suggests that some of the fat in your body-the kind called brown fat-burns up calories when it is cold. So, according to Adrenaline RE-search, if you leave those areas exposed when the temperature falls rather than wrapping them up with clothes, you can “control your weight”...Adrenaline RE-search has produced a special fashion range called CLOtherapy, designed to keep those brown fat areas cool.’

94.04. Paculla, T. (1994): Cool Clothes and Vanishing Creams. Marie Claire Health and Beauty, Spring, p142.
‘You could turn up your own thermostat by wearing less clothing. In the young and healthy, exposure to cold is well known to boost metabolic rates. There is evidence that cooling can switch on your ‘brown fat’ cells. CLOtherapy is a new treatment consisting of clothing designed to do just this. This controlled cooling may also improve circulation and the immune system.’

93.02. Love, E. (Editor) (1994): Exercising Brown Fat Generates Heat and Controls Weight. Medical Textiles, Feb, p6.
‘The new range of clothing - CLOtherapy...incorporates specially selected sections of fabric which let key areas of the brown fat feel the outside temperature. Because it is designed to help the brown fat to function efficiently, the clothing can help the wearer to control his or her weight.’

93.02. Jones, H. (TV’s Dr Hilary Jones) (1993): GMTV, ITV, 03 Feb, 06:50.
‘Yeah, they do look great’. (CLOtherapy Clothing)

94.06. Jennings, C. (1994): Five things that will change your life. European éLAN, 10 -16,Jun, p2-3.
‘What’s going to be big in the next five to ten years?...Clever Clothes...Adrenaline-REsearch...Makes a range of intelligent thermo-regulatory clothing, which will keep your armpits, backbone, groin and breastbone cool, while keeping the rest of you warm.’

94.07. (1994): Clothes wear away those layers of fat. Sunday Telegraph, 17 Jul, p18.
‘Get dressed and lose weight.’

94.09. Clayton, P. R. (1994): Can you lose weight by putting on a sweatshirt? Daily Mail, 06 Sep, p36.
‘The combination of warmth, together with the coolness generated by the thermal panels, is surprisingly comfortable.’

93.05. Farquharson, M. (1993): Healthwise. Here’s Health, May, p8.
‘ You are what you wear...CLOtherapy is a completely new theory... the clothes come with a 30-day money back guarantee.’

adrenalin.tm - reviews 2 >

The CLOtherapy Polo-shirt is currently available, for fast delivery,

93.02. Seymour, I. (Ian Seymour - SKY TV Presenter) (1993): Sunrise. SKY News. 03 Feb, 08:47-08:52 & 12:00.
‘They call them “ADRENALIN” T-shirts and tracksuits. The system is simple-allowing air to cool parts of the body that sweat a lot like under your arms and down your back. Being cool you burn off more fat trying to warm up. It’s all very simple. It’s those white fat cells that we often find around our midriffs-It’s those white fat cells we want to burn off.’

96.02. Ashdown P, Kirkwood A, Steel D Sir. (Liberal Democrat MPs) (1996): Look Around. Borders Television, 23 Feb, 13:30.
‘Who’s idea was this?...Good idea...Should create jobs...’

93.11. Smullen, I. (1993): Dressed to Chill. Longevity (USA), Nov, p22-23.
‘The concept is based on the idea that brown fat, a version of adipose tissue whose main role is to burn energy as heat, can be revved up by exposure to cold...the line of cotton sweats, T’s and such have mesh panels in the places brown fat hangs around-armpits, backbone, breastbone, groin...to chill out those spots and supposedly trick the body into turning up the regular-fat-burning heat.’

93.04. Wright, J. (1993): Dressed For Excess. Health and Fitness, Apr, p19.
‘It seems we have lots of chubby white fat cells in our bodies, which store fat in case we should ever need it, and a smaller supply of very helpful brown fat which leaps into action when we get cold and coverts the other fat into heat.’

93.02. Pope, N. (1993): Clothes that Help You Slim. Today, 03Feb, p17.
‘To help keep you warm, the clothes are padded where brown fat does not occur.’

93.02. Gregory, L. (1993): Fat Busters. Yorkshire on Sunday, 14 Feb.
‘The result is CLOtherapy garments, designed to make use of so-called brown and white fat cells in our body.’

93.02. Thorne, H. (Helen Thorne - Fashion Presenter) (1993): GMTV. ITV, 03 Feb, 06:50.
‘On a fashion note, I think the quality of the clothing is very good...they do look good.’

93.03. Marshall, K. (1993): Clothes to keep you thin. Printwear & Promotion, Mar/Apr, p42.
‘Central to the theory is the function of a fat-burning tissue in the body called brown fat. This innovative clothing not only looks good and is fashionable, but is the world’s first designed to facilitate rapid ‘on-off’ control of brown fat to allow it to freely convert fuel into heat whenever you need to.’

93.02. Armstrong, F. (Fiona Armstrong - TV Presenter) (1993): GMTV. ITV, 03 Feb, 06:50.
‘Sports clothing designed to control your weight...Just look like ordinary sports garments.’

93.02. Stevens, G. (Gary Stevens - Tottenham & England Footballer) (1993): GMTV. ITV, 03 Feb, 06:50.
‘The truth is it’s hard work to keep fit. I’m actually going to speak to Trevor (Trevor Gunn-Adrenaline-REsearch) and see if I can borrow one of those tops.’

94.12. Turner, C. (Health/Beauty Editor) (1994): Fatty Issue. Company, Dec, p20.
‘Called Thermo-Regulatory Clothing, it works on the theory that our bodies contain two types of fat...Enter Adrenaline-REsearch’s new CLOtherapy SWEATshirt...temperature-sensitive nerves send messages to the brain, telling it to use brown fat...burning more calories...at £39.95 who’s expecting Versace? For more information, contact Adrenaline-REsearch on 04269 54321’

93.02. Finnigan, J. (Judy Finnigan - TV Presenter) (1993): This Morning, ITV. Granada TV, 08 Feb, 11:20.
‘This kind of sports gear ...apparently works wonders...they’re the latest kind of scientifically designed sportswear ...to burn off fat.’

93.02. Friend, B. (Bob Friend - SKY TV Presenter) (1993): Sunrise. SKY News, 08:47-08:52 & 12:00.
‘This is an encouragement to general fitness...I suppose with this it’s very warm anyway...You can wear this out and keep warm...Very cheap, very reasonable I think...You’re watching ‘Sunrise’ slim version!’

93.02. Smith, P. (Penny Smith - SKY TV Presenter) (1993): Sunrise. SKY News, 03 Feb, 08:47-08:52 & 12:00.
‘So basically what we should all do is run around our houses with the clothing on and let the cold air in and keep warm that way.’

93.02. Clayton, P. R. (Dr Paul Clayton - Health Editor, Woman’s Journal) (1993): Practical Living. UK Living, Sep.
‘There’s a fascinating new therapy that’s been devised by a team of...very interesting scientists...They have something they call clothing therapy or CLOtherapy that looks like ordinary T-shirts or sweatshirts but they have a panel down your backbone which is ventilated and it looks as if by cooling the spine, which is where the nerve endings are that detect your body temperature, that you can encourage the brown fat...Like having your own central heating you can switch it on and start burning calories. ’

93.09. Irving, J. (Jayne Irving - UK Living TV Presenter) (1993): Practical Living. UK Living, Sep.
‘I was really fascinated to read that there’s a new way you can lose weight which involves just taking your jacket off and driving while it’s quite cold with the window open. ’

93.09. Clayton, P. R. (Dr Paul Clayton - Health Editor) (1993): Your body how it will look 5, 10, 20, years from now. Woman’s Journal, Sep, p48-51.
‘ Some scientists believe that slow burners have less adrenaline and burn off less excess calories as body heat, storing it as fat intead - The cooling method may be especially effective for these people. One such method, CLOtherapy - a range of leisurewear that incorporates cooling panels - is in it’s early stages, but evidence suggests you can burn more calories just by wearing the clothes.’

93.02. Raiment, S. (1993): Sun, Apr, p36.
‘A range of outfits called CLOtherapy which let cool air reach the vital “Brown fat cells.’

93.04. McLoughlin, J. (1993): Fighting the flabby. New Woman, Apr, p36.
‘Some parts of the body burn up calories when they get cold.’

98.07. Murray, G. (1998): Smart shirt is good for your health. Scotland on Sunday, Jul 19, p8.
'It's the latest fashion accessory for the beautiful people - a shirt that claims to improve muscle tone and blood circulation while burning off fat just by keeping the wearer's spine cool... Last week, Men's London Fashion Week, saw a whirl of designer sideburns, bum-hugging slacks and way out looks paraded on the catwalk. But Gracey says that his shirts could signal the real future for fashion...

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BAT IN MICE AND MEN - Nature magazine 23/30 December 1993 reports on new findings from the USA and Canada by Dr Bradford Lowell, Professor Jean Himms-Hagen and colleagues: As Brown Adipose Tissue (BAT) between the shoulder blades in mice switches off, mice become more sensitive to the cold, they get very fat and their appetite increases - As BAT switches back on their weight returns to normal. This long-awaited but major breakthrough in clarifying the massive role of brown fat (BAT) in preventing long-term obesity, follows pioneering British researchers Dr Nancy Rothwell and Professor Michael Stock's findings, published over 15 years ago in Nature (issue 6 September 1979), suggesting that many men (and women) likely possess significantly active brown fat especially in areas such as the back, breastbone and neck that can be switched on (for some reason) when they eat excess calories; I report now on a new way to help regulate brown fat - again from Britain - that of The science of CLOtherapy - improving the environmental temperature of the nervous system, and so your vitality, by redressing the fat thermostat; Adrenaline-REsearch (A-RE) have reclassified Brown Fat's first and foremost role as a STRESS ADAPTIVE TISSUE - vital to our health and well-being.

CLOTHING FOR BROWN FAT © Editorial & Testing By Dr Paul R. Clayton - R & D, Boots The Chemist (UK).

High performance 'more heat generating' series 5 computer cpu/chips need more temperature control, by way of vents and cooling fins, than say the generally more reliable less heat generating series 4 cpu/chip; So how might this computer analogy be interesting when questioning your temperature control and its relationship to the health and heat generation of your nervous system?... Government statistics show that one in eight people are grossly overweight and in view of the fact that healthy weight control takes time... What's the healthiest way to be overweight while you shed that bulky fat? Crash diets don't work for long and approximately 98% of diets fail in the long run. You could try cutting out chocolate, biscuits and beer for the rest of your natural life. You could make a New Year’s resolution to sweat with a frenzy as you jog 5 miles every day, come hail or high water. Or, you could change your clothing. New research suggests that properly designed clothes can have a profound effect on your metabolism, your weight, and your health. The message for the under active/overweight is to keep your nervous system stimulated & cool and so allow naturally generated warmth from increases in nervous activity help build muscle and shed fat; the overactive/underweight should aim to cool their nervous system in order to stimulate appetite and to prevent heat-induced weight losses of vital tissue. It might sound strange - but this new approach to vitality and weight control, called CLOtherapy training, is supported by an increasing body of international research... And it’s mostly a matter of fat.

BROWN FAT - WHITE HEAT

Our bodies contain many different kinds of fat, some is the vital myelin nerve fat which is vital in helping maintain a healthy nervous system; most is white bulky fat, a usually sluggish bulky tissue which stores excess calories, and increases our waist size. But we also have small amounts of brown stress adaptive fat which is profoundly efficient and can be very aerobically/metabolically active leading it to generate large amounts of heat. Babies have brown fat, but until recently most doctors thought it disappeared as we grow older.

That idea, however, is changing. Dr Pirkko Huttunen, who is Vice-President of the International Society for Adaptive Medicine, studied indoor and outdoor workers in Northern Finland, where the climate is usually cool or cold. The office workers apparently had no brown fat but outdoor workers, such as lumberjacks, did. Dr Huttunen believes the body adapts to cold by growing pockets of brown fat in areas of exposed skin which allow the body to rev up its central heating, burning blood fats and sugars instead of coal. Back in the stone age, brown fat was likely essential, says Dr Huttunen. How else could we keep warm through the long glacial winters? But nowadays office jobs, central heating and warm clothing ensure that our bodies are seldom exposed enough, to stimulate the cold-associated growth of brown fat; so the brown fat we have as babies usually fades away. This explains why few other scientists have found brown fat in adults. Basically, we need to exercise to train our brown fat.

COOL DOWN - WARM UP

Dr Huttunen has found significant amounts of this aerobic brown fat in the armpits and neck of adults and children. She and others believe there are special temperature-sensitive nerves close to the skin’s surface in certain areas of the body, including the neck, breastbone/solar plexus and the spine. If these nerves are exposed to the stimulating stress of cool temperatures, they send a message to the hypothalamus in the brain, telling it that it's okay to raise the thermostat. The brain then allows the skin's brown fat areas to start shedding excess fuel and, the heat that this activity generates, may help raise the body temperature back up to normal.

Professor George Bray of the Pennington Biomedical Research Center, Louisiana, USA, found that certain stimuli cause the body to start heating up, and his team are convinced that brown fat is involved. Professor Bray: ‘We are becoming aware that brown fat has a very specialised function. Even though there's not much brown fat in a typical adult, up to about 1% of the body by weight, when it gets revved up it produces as much heat as the rest of the body combined.

This probably explains why some people (usually, the heated nervous stress types) can overeat and remain slim; their brown fat enables them to shed excess calories/lagging rather than store them as extra heat storing fatty lagging (which, without effi cient cooling, in such a heated/activity type person could easily lead to a nervous system burnout situation or a loss of vitality); but what about those who eat sparingly, yet still put on the white bulky fat? Professor Bray can explain that too: One reason for obesity may be that certain people are not able to burn off calories as heat, and store them instead as white fat. This could be why older people tend to put on weight, because with aging brown fat becomes less efficient, and less able to burn unwanted calories.

Brown fat is emerging as a key factor associated to whether we’re lean or fat. But is it possible to develop brown fat without going to Finland to work as a lumberjack? The answer is almost certainly yes. New work, by Stéphane Krief, Daniel Ricquier, and colleagues, at the University of Paris has shown that in both adults and children, dormant brown fat cells can be turned into active brown ones whenever (apparently) the nervous system directs the shedding of excess fats; Increasing (A) Fat breakdown and (B) Fat excretion from the intestines. Other studies, around the world, suggest that to increase the efficiency of your active brown fat: Exercise regularly in cool temperatures to train your aerobic ability to generate your own warmth by exercising, put the thermal underwear back in cold storage, and save on those fuel bills by turning down the central heating... American Scientists, and writers, Durk Pearson and Sandy Shaw agree with the importance of cooling, but emphasise the importance of keeping active. Exercise usually causes a rise in body temperature, which can suppress brown fat formation; but exercise which is not accompanied by rise in body temperature, such as swimming in cool or lukewarm water, increases brown fat in experimental animals, and boosts their metabolism.

COLD BATHS - TRHT

The idea that a chilly dip could be good for health was supported recently when Professor Vijay Kakkar, head of the Thrombosis Institute in London, suggested that a daily cold bath regime, called Thermo-Regulatory Hydro-Therapy (TRHT), stimulated brown fat, boosted the immune system, improved the circulation, relieved asthma, treated ME, regulated oestrogen / testosterone production and improved hair texture - All through exercising temperature control! ...Regular cold baths are an acquired taste, and take some mastering even if they can stimulate brown fat, so is there an alternative? At the AFRC Babraham Research Institute in Cambridge, Dr Joy Dauncey has been studying the effects of warm and cool environments on the metabolic rate. She found that at a stimulating temperature of 22 degrees Centigrade (which is cool, but warm enough to minimise shivering), her experimental women subjects boosted their metabolism by as much as 10%. This important research proved that a slight cooling of the body may trigger the brown fat, and start it burning calories which can help to maintain body temperature.

At Trinity College, Dublin, Dr Juliet Heaton, discovered brown fat in all age groups from babies to adults aged 80; most importantly her work suggests that the type of brown fat found at the skin's surface, for example between the shoulder blades, is most sensitive to the brown fat activating effects of cool temperatures. In separate studies on metabolic responses of young men and women to cold stress, researchers Andrews and Jackson at Trinity College, Dublin discovered that the more obese we become (especially women), the more our nervous system reduces heat output in response to stress. Dr Fred Andrews: This effect could compound the problem of weight loss in obesity. So is there a comfortable way of exercising an increased metabolic shedding response to stress if you're overweight and reducing the stress response if you're underweight?

Professor Jean Himms-Hagen has been studying subtle effects of animal housing temperatures on brown fat at the University of Ottawa, Canada; Her work has hinted that brown fat 'stress-adaptive thermogenesis' is reduced in the overclothed/overweight, whilst it is increased in the underclothed/underweight. At the Hove Clinic in Sussex, Adrenaline-REsearch (A-RE), a research team led by medical biochemist Trevor Gunn, are testing a patented STRESS-ADAPTIVE TRAINING, range of warm CLOtherapy sportswear with 'coolzones' over the armpits, backbone, breastbone, groin and neck. Even when standing still, these 'coolzones' give the nerves an invigorating cool air massage, and even better, provide for 'stress-release' by allowing any sweat to rapidly evaporate, cool and dry these sweaty skin regions - for safer, more comfortable, exercising. A-RE pioneering theory states that as nervous activity/stress raises temperature within nervous tissue - insulatory white fat is adaptively shed to help keep nerves cool and vital; this results in increased blood fats which need to be mopped up (see below) from the blood stream. A-RE are also marketing CLOtherapy SWEATshirts to assist in training improved weight control by the overweight and underweight; For the overweight, exercising local cooling is employed to encourage the growth of brown fat, speed the rate at which excess food is converted into heat and gently shed those surplus pounds of white fat. It’s a new science called CLOtherapy, focused on improving/training the environmental adaptability of the nervous system, and the medical community are intrigued.

Dr Catherine Geissler is head of the Department of Nutrition at London's King's College. It might work, but I should need to see more evidence. It's true that cooling the body, by wearing less clothes for example increases the amount of calories you burn - but I'm not convinced that local cooling would have the same effect. We just don't know enough about brown fat in humans. But it's certainly an interesting approach, and worth investigating.

Scientists at Adrenaline-REsearch are seeking a wider discussion of their theory that brown fat's first and foremost function is a vital blood cleansing mechanism, acting in an analogous way to the lymph system and playing a fundamental role in both babies and adults health; Trevor Gunn (also a qualified homeopath) is confident of our body's increased capacity to heal instinctively when given an improved thermal environment; Trevor believes that exercising local cooling, especially of the thymus gland, solar plexus and spinal cord, can really help us train our immune & nervous systems to react more positively to stress: There are plenty of animal studies which show that if you cool the nerve endings in the spine, nervous activity can be increased; Stimulate the sensory nerves in the key COOLzone sites by local cooling, for as long as comfortably possible each day - whilst keeping warm and active, and that nervous system training should be enough to help control the activity of your stress-adaptive tissue Brown Fat which can mop up and burn off excess sugars and fats from the bloodstream... So important is our capacity for local nervous system cooling that three eminent University Professors-Michael Cabanac (Quebec), Peter Wheeler (Liverpool) and US fossil expert, Ms Dean Falk suggest that to increase intelligence and dexterity, the need to cool the brain and spinal cord drove ape man to stand up! Our next evolutionary jump is ?...

WINTER OF CONTENT

I was initially skeptical, but agreed to try CLOtherapy training for a few months over the winter. I'm lean, and I didn't lose weight - but then again, I didn't want to. What did happen was that I started eating 5 or 6 square meals a day. I was ravenous, constantly eating, but my weight stayed exactly where it was. All the fatty strain of that excess food was being burned up and converted to heat. My nervous activity and temperature increased to such an extent that I could no longer bear to sleep under a duvet, even on the coldest nights, and slept instead under a single sheet. Colleagues and friends remarked that I was sometimes hot to the touch, and asked if I had a fever - but I remained free of colds and flu throughout the winter... The verdict, then, on CLOtherapy? Well, the Health Education Authority recommends 16 - 20 degrees Centigrade for babies room temperature at night; Adrenaline-REsearch suggests, for optimum health / core (nervous system) temperature regulation, we should all train our ability to generate interval warmth and so adapt our 'coolzones' to be comfortable at 22 degrees 24hrs a day, which seems reasonable. The experts are still undecided, but on the basis of my experience with the 'CLOtherapy SWEATshirt', over a period of several months, CLOtherapy training really does make a difference. If you can control your appetite as you train your brown fat to go into action, your excess white fats, like the snows of yesteryear, should gradually melt away.

OUR PORTABLE CLIMATE

Whilst traditional exercise and a calorie-controlled nutrition plan may help you achieve your target weight, (when used alone or in conjunction with CLOtherapy training), according to Dr Dauncey, gentle 22 degrees Centigrade cooling stimulation, even if applied for only 10% of the time, could result in a slow but sure average weight loss of 8 kilograms (17.5 pounds) over the course of ten years. Professor Michael J. Lean, Glasgow University, found similar results in his studies on obese women. For anyone significantly overweight, in search of quicker results, increased awareness of your skin's environment (what's the temperature of your portable climate - beneath YOUR clothes - right now?!) continuous cooling and periodic gentle 'warm up' exercises (comprising CLOtherapy training) at a comfortable 22 degrees Centigrade could increase nervous activity and improve muscle tone sufficient to lead to a yearly shedding of a full stone of white fat (which stays off!); For anyone underweight, research suggests that cooling the nervous system, and so reducing heat stress, can increase appetite, muscular and other vital tissue weight. So, if you have been eating the same as your underweight partner and are still piling on the pounds - maybe the time has come to redress the stress balance by redressing your nervous system?

Adrenaline-REsearch are keen for You to test out their theories; they too, want to know how well the CLOtherapy SWEATshirt will work for You (there's a full 30 day & special 12 month money back guarantee). They are seeking customer participation and feedback from interested individuals wishing to participate in the 1998 CLOtherapy Philosophy health programme, focused on improving the immune system, vitality and long-term weight control; A new business opportunity as a Licenced CLOtherapy Distributor is offered to TRUE GRIT individuals with a passion good communication! For a free poster about the CLOtherapy Philosophy and the new 1998 range, please write to Adrenaline-REsearch (A-RE), CLOtherapy House, Tweed Horizons, Melrose, TD6 0SG, UK; (TEL) : +44 (0) 7000-78-2434 (24hr) or (FAX): +44 (0) 7000-78-1212 or (E-mail) mailto:[email protected] on the (WEBSITE) @ 'http://www.clotherapy.com'

Dr Paul Clayton is a medical scientist researching into longevity, nutrition and stress; Dr Clayton is former Health Editor of Woman's Journal and a regular writer for Marie Claire magazine.

Adrenaline-REsearch sponsors
'The1998 Kelso Laddie - Craig Scott' with a CLOtherapy'98 Polo-shirt.

Adrenaline-REsearch, Tweed Horizons,
Centre for Sustainable Technology,
Melrose, Scotland, TD6 0SG, UK.
(F): + 44 (0) 7000-78-1212
(I): [email protected]
(T): + 44 (0) 7000-78-2434

Fax: +44 (0) 7000 - adrenalin.tm (237-362) .......... E-mail: [email protected] .......... +44 (0) 7000 - CLOtherapy... (256-843)

Adrenalin Site Under Construction

[email protected]

Watch this space for details over the next month or click on related sites.

Adrenaline-REsearch, Tweed Horizons, Centre for Sustainable Technology, Melrose, Scotland, TD6 0SG, UK. (F): + 44 (0) 7000-78-1212 (I): [email protected] (T): + 44 (0) 7000-78-2434

Fax: +44 (0) 7000 - adrenalin.tm (237-362) .......... E-mail: [email protected] .......... +44 (0) 7000 - CLOtherapy... (256-843)

Adrenalin Site Under Construction

[email protected]

Watch this space for details over the next month or click on related sites.

Adrenaline-REsearch, Tweed Horizons,
Centre for Sustainable Technology,
Melrose, Scotland, TD6 0SG, UK.
(F): + 44 (0) 7000-78-1212
(I): [email protected]
(T): + 44 (0) 7000-78-2434